Priorities in Parkinson's disease research
Identifieur interne : 000184 ( Main/Exploration ); précédent : 000183; suivant : 000185Priorities in Parkinson's disease research
Auteurs : Wassilios G. Meissner [France] ; Mark Frasier [États-Unis] ; Thomas Gasser [Allemagne] ; Christopher G. Goetz [États-Unis] ; Andres Lozano [Canada] ; Paola Piccini [Royaume-Uni] ; José A. Obeso [Espagne] ; Olivier Rascol [France] ; Anthony Schapira [Royaume-Uni] ; Valerie Voon [Royaume-Uni] ; David M. Weiner [États-Unis] ; François Tison [France] ; Erwan Bezard [France]Source :
- Nature Reviews Drug Discovery [ 1474-1776 ] ; 2011-05.
Abstract
The loss of dopaminergic neurons in the substantia nigra pars compacta leads to the characteristic motor symptoms of Parkinson's disease: bradykinesia, rigidity and resting tremors. Although these symptoms can be improved using currently available dopamine replacement strategies, there is still a need to improve current strategies of treating these symptoms, together with a need to alleviate non-motor symptoms of the disease. Moreover, treatments that provide neuroprotection and/or disease-modifying effects remain an urgent unmet clinical need. This Review describes the most promising biological targets and therapeutic agents that are currently being assessed to address these treatment goals. Progress will rely on understanding genetic mutations or susceptibility factors that lead to Parkinson's disease, better translation between preclinical animal models and clinical research, and improving the design of future clinical trials.>
Url:
DOI: 10.1038/nrd3430
Affiliations:
- Allemagne, Canada, Espagne, France, Royaume-Uni, États-Unis
- Angleterre, Angleterre de l'Est, Aquitaine, Aquitaine-Limousin-Poitou-Charentes, Bade-Wurtemberg, Communauté forale de Navarre, District de Tübingen, Languedoc-Roussillon-Midi-Pyrénées, Midi-Pyrénées, Ontario
- Bordeaux, Cambridge, Toronto, Toulouse, Tübingen
- Université Toulouse III - Paul Sabatier, Université de Bordeaux, Université de Cambridge, Université de Toronto, Université de Toulouse
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Weiner</name><affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>EMD Serono, Rockland, Massachusetts 02370</wicri:regionArea><wicri:noRegion>Massachusetts 02370</wicri:noRegion></affiliation></author><author><name sortKey="Tison, Francois" sort="Tison, Francois" uniqKey="Tison F" first="François" last="Tison">François Tison</name><affiliation><wicri:noCountry code="subField">3604 Pessac France.</wicri:noCountry></affiliation><affiliation wicri:level="4"><country xml:lang="fr">France</country><wicri:regionArea>Université de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, F-33000 Bordeaux</wicri:regionArea><placeName><region type="region" nuts="2">Aquitaine-Limousin-Poitou-Charentes</region><region type="old region" nuts="2">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName><orgName type="university">Université de Bordeaux</orgName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>CNRS, Institut des Maladies Neurodégénératives, UMR 5293, F-33000 Bordeaux</wicri:regionArea><placeName><region type="region" nuts="2">Aquitaine-Limousin-Poitou-Charentes</region><region type="old region" nuts="2">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Bezard, Erwan" sort="Bezard, Erwan" uniqKey="Bezard E" first="Erwan" last="Bezard">Erwan Bezard</name><affiliation><wicri:noCountry code="subField">3604 Pessac France.</wicri:noCountry></affiliation><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>CNRS, Institut des Maladies Neurodégénératives, UMR 5293, F-33000 Bordeaux</wicri:regionArea><placeName><region type="region" nuts="2">Aquitaine-Limousin-Poitou-Charentes</region><region type="old region" nuts="2">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Nature Reviews Drug Discovery</title><idno type="ISSN">1474-1776</idno><idno type="eISSN">1474-1784</idno><imprint><publisher>Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.</publisher><date type="published" when="2011-05">2011-05</date><biblScope unit="volume">10</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="377">377</biblScope><biblScope unit="page" to="393">393</biblScope></imprint><idno type="ISSN">1474-1776</idno></series><idno type="istex">B18DB94A38D88A12D621F99E69D4EEFEBBE7059E</idno><idno type="DOI">10.1038/nrd3430</idno><idno type="ArticleID">nrd3430</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1474-1776</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="eng">The loss of dopaminergic neurons in the substantia nigra pars compacta leads to the characteristic motor symptoms of Parkinson's disease: bradykinesia, rigidity and resting tremors. Although these symptoms can be improved using currently available dopamine replacement strategies, there is still a need to improve current strategies of treating these symptoms, together with a need to alleviate non-motor symptoms of the disease. Moreover, treatments that provide neuroprotection and/or disease-modifying effects remain an urgent unmet clinical need. This Review describes the most promising biological targets and therapeutic agents that are currently being assessed to address these treatment goals. Progress will rely on understanding genetic mutations or susceptibility factors that lead to Parkinson's disease, better translation between preclinical animal models and clinical research, and improving the design of future clinical trials.></div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Canada</li><li>Espagne</li><li>France</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Angleterre de l'Est</li><li>Aquitaine</li><li>Aquitaine-Limousin-Poitou-Charentes</li><li>Bade-Wurtemberg</li><li>Communauté forale de Navarre</li><li>District de Tübingen</li><li>Languedoc-Roussillon-Midi-Pyrénées</li><li>Midi-Pyrénées</li><li>Ontario</li></region><settlement><li>Bordeaux</li><li>Cambridge</li><li>Toronto</li><li>Toulouse</li><li>Tübingen</li></settlement><orgName><li>Université Toulouse III - Paul Sabatier</li><li>Université de Bordeaux</li><li>Université de Cambridge</li><li>Université de Toronto</li><li>Université de Toulouse</li></orgName></list><tree><country name="France"><region name="Aquitaine-Limousin-Poitou-Charentes"><name sortKey="Meissner, Wassilios G" sort="Meissner, Wassilios G" uniqKey="Meissner W" first="Wassilios G." last="Meissner">Wassilios G. Meissner</name></region><name sortKey="Bezard, Erwan" sort="Bezard, Erwan" uniqKey="Bezard E" first="Erwan" last="Bezard">Erwan Bezard</name><name sortKey="Meissner, Wassilios G" sort="Meissner, Wassilios G" uniqKey="Meissner W" first="Wassilios G." last="Meissner">Wassilios G. Meissner</name><name sortKey="Meissner, Wassilios G" sort="Meissner, Wassilios G" uniqKey="Meissner W" first="Wassilios G." last="Meissner">Wassilios G. Meissner</name><name sortKey="Rascol, Olivier" sort="Rascol, Olivier" uniqKey="Rascol O" first="Olivier" last="Rascol">Olivier Rascol</name><name sortKey="Tison, Francois" sort="Tison, Francois" uniqKey="Tison F" first="François" last="Tison">François Tison</name><name sortKey="Tison, Francois" sort="Tison, Francois" uniqKey="Tison F" first="François" last="Tison">François Tison</name></country><country name="États-Unis"><noRegion><name sortKey="Frasier, Mark" sort="Frasier, Mark" uniqKey="Frasier M" first="Mark" last="Frasier">Mark Frasier</name></noRegion><name sortKey="Goetz, Christopher G" sort="Goetz, Christopher G" uniqKey="Goetz C" first="Christopher G." last="Goetz">Christopher G. Goetz</name><name sortKey="Weiner, David M" sort="Weiner, David M" uniqKey="Weiner D" first="David M." last="Weiner">David M. Weiner</name></country><country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Gasser, Thomas" sort="Gasser, Thomas" uniqKey="Gasser T" first="Thomas" last="Gasser">Thomas Gasser</name></region></country><country name="Canada"><region name="Ontario"><name sortKey="Lozano, Andres" sort="Lozano, Andres" uniqKey="Lozano A" first="Andres" last="Lozano">Andres Lozano</name></region></country><country name="Royaume-Uni"><noRegion><name sortKey="Piccini, Paola" sort="Piccini, Paola" uniqKey="Piccini P" first="Paola" last="Piccini">Paola Piccini</name></noRegion><name sortKey="Schapira, Anthony" sort="Schapira, Anthony" uniqKey="Schapira A" first="Anthony" last="Schapira">Anthony Schapira</name><name sortKey="Voon, Valerie" sort="Voon, Valerie" uniqKey="Voon V" first="Valerie" last="Voon">Valerie Voon</name></country><country name="Espagne"><region name="Communauté forale de Navarre"><name sortKey="Obeso, Jose A" sort="Obeso, Jose A" uniqKey="Obeso J" first="José A." last="Obeso">José A. 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